Reviewer Recommendation and Comments for Manuscript Number CBTO548 Cytotoxicity of herbicide Roundup and its active ingredient, glyphosate in rats Original Submission

Regulatory agencies world wide such as the United States Environmental Protection Agency (1993; 2006) and the European Commission (2002) as well as scientific organizations such as the World Health Organization (2004), whose responsibilities are to evaluate the use of pesticides and determine their safety for human health and the environment have concluded after reviewed extensive data sets that glyphosate has low toxicity to humans and wildlife, is not a carcinogen, not a mutagen, not a teratogen, is not neurotoxic and is not a reproductive toxicant and when used according to label directions do not pose unreasonable risks to human health and the environment.